[Table/Fig-2]:
Parameters of ADRs
| Parameters | ADR among TB patients on ATT | ADR among TB patients With HIV on ATT and HAART |
Statistical analysis |
|---|---|---|---|
| Severity of ADRS – Mild/ Moderate/ Severe/ Fatal | 2(2.7%)/53(71.6%)/19(25.7%)/0(0%) | 4(8.8%)/25(55.6%)/16(35.5%) | χ2=4.15; p=0.12; NS |
| Mode of onset – Sub acute/ Acute/ Latent | 7(9.5%)/12(16.2%)/55(74.3%) | 9(20.0%)/2(4.5%)/34(75.5%) | χ2=5.61; p=0.06; NS |
| Type of reactions - A,B,C,D,E & Unclassified | 65(87.83%)/1(1.13)/ 8(10.8)/0(0%)/0(0%) | 28(62.2%)/6(13.3%)/11(24.44%)/0(0%)/0(0%) | χ2=12.44; p=0.001; HS |
| Causality as per Naranjo’s Scale - Definite/Probable/Possible/Doubtful | 0/31(41.9%)/43(58.1)/0(0%) | 0((0%)/21(46.7%)/24(53.3%)/0(0%) | χ2=0.26; p=0.61;NS |
| Causality as per WHO - UMC scale –Certain/Probable/Possible/Unlikely/Unclassified/Unassessible | 0/31(41.9%)/43(58.1)/0(0%)/0(0%)/0(0%) | 0(0%)/21(46.7%)/24(53.3%)/0(0%)/0(0%) | χ2=0.26; p=0.61;NS |
| Outcome of the ADRs - Recovered/Recovering/Continuing/Unknown | 62(83.8%)/12(16.2%)/0(0%)/0(0%) | 29(64.4%)/15(33.4%)/1(2.2%) | χ2=6.63; p=0.03;S |
| Management of ADRs - Intervention required Vs No Intervention Required | 21(28.4%) Vs 53 (71.6%) | 17(37.8%) Vs 28 (62.2%) | χ2=31.79; p=0.0001; HS |
S= significant, NS= Non significant; HS= Highly significant