Female rats that were virgin, lactating (14-19 postpartum), or weaned (21 days postpartum)(N=5, each) were sacrificed after either no stress (NS), 20 minutes (20) or 24 hours (24) following a single restraint episode. Lactating rats had significantly reduced levels of stress-induced tau-P at both PHF-1 and AT8 epitopes compared to virgin (p=0.008) and weaned rats (p=0.008); however, tau-P returned to control/basal levels after 24 hours. Data are presented as percent change ± SEM.