Figure 3. GSK3 levels in control and stressed lactating rats.
Lactating rats were sacrificed after no stress (NS), or 20 minutes (20) or 24 hours (24) (N=5, each) following acute restraint stress. Twenty minutes after stress, lactating rats had significantly lower levels of total hippocampal GSK3-α compared to their controls (p=0.008) and these low levels were sustained 24 hours later (p=0.008). However, 24 hours following stress, active GSK3-β levels increased compared to control (p=0.016), although active GSK3-α levels stayed relatively the same. There were no significant changes in inactive GSK3 (both α and β) levels. Data are presented as percent change from NS condition ± SEM.