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. 2014 Nov 22;22(6):780–788. doi: 10.1016/j.sjbs.2014.11.005

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© 2014 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

PMC Copyright notice

Light photomicrographs of sections in lungs of different animal groups showing control for different degrees of asthma (H & E). (A) Normal small bronchus (BR) without detectable inflammatory reaction showing intact epithelium (E), blood vessel (BV) and alveoli (AV). (B) Focal perivascular inflammatory cells (arrow head) around small bronchus (BR). Slight oedema appears in epithelial layer (E) and inflation of alveoli (AV) in mild asthma. (C) All-around peribronchial (BR) and perivascular (BV) inflammation (arrow heads) forming less than 5 cell-deep layers with more oedematous epithelium (E) and inflation of alveoli (AV) in mild persistent asthmatic mice. (D) All-around peribronchial (BR) and perivascular (BV) inflammation (arrow heads) forming more than 5 cells-deep layers with inflated alveoli (AV) and burst fused others forming emphysema (EP) in severe asthmatic cases.