Table 1.

Baseline demographics and clinical characteristics

Parameter	Never smokers	Smokers w/o COPD	GOLD I-II COPD^b	GOLD III-IV COPD^c	p ANOVA
Subjects (n)^a	8	6	18	12
Gender (female/male)	6/2	3/3	5/13	6/6
Age (years)	63 ± 4.8	56 ± 3.2	68 ± 1.8	61 ± 1.2	<0.05
Height (m)	1,64 ± 0.033	1.72 ± 0.05	1,74 ± 0.02	1,7 ± 0.031	ns
Weight (kg)	64,6 ± 4.6	69.2 ± 4.4	73,1 ± 3.5	67,7 ± 4.1	ns
Body mass index	23,9 ± 1.3	23.3 ± 1.1	24,4 ± 1.1	23,3 ± 0.94	ns
Pack years	N/A	43 ± 9.7	45 ± 3.5	41 ± 3.2	ns
Smoker/ex-smoker	N/A	3/3	7/11	0/12
FEV1/FVC	85,9 ± 5.7	77.8 ± 2.4	61,4 ± 1.9	33,4 ± 2.1	<0.001
FEV1 (% of predicted)	109,8 ± 6.2	93.8 ± 4.2	74,1 ± 2.7	26,2 ± 2.7	<0.001
Corticosteroids (yes/no/unknown)	0/8/0	0/6/0	2/16/0	9/2/1
Bronchodialator (yes/no/unknown)	0/8/0	0/6/0	6/12/0	9/2/1

^aAll surgeries were performed at Skåne University Hospital, in Lund, Sweden

^bTissue samples were obtained during lung resection surgery for bronchial tumour

^cTissue samples were obtained from GOLD II COPD patients during lung resection surgery for bronchial tumour, and from GOLD IV COPD patients during lung transplantation