Table 4.

Reclassification statistics for ProADM and the three endpoints

	Mortality	ICU admission	High treatment priority
Models including clinical information readily available at ED admission
Net reclassification improvement (NRI)	0.11 (SE 0.03), p = 0.00004	0.06 (SE 0.02), p = 0.01345	0.02 (SE 0.01), p = 0.00572
Integrated discrimination improvement (IDI)	0.04 (SE 0.01), p = 0.0001	0.01 (SE 0.01), p = 0.0001	0.02 (SE 0.01), p = 0.0001
Models including full clinical information available at ED discharge
Net reclassification improvement (NRI)	0.09 (SE 0.02), p = 0.0003	0.08 (SE 0.02), p = 0.0001	0.02 (SE 0.01), p = 0.0072
Integrated discrimination improvement (IDI)	0.04 (SE 0.01), p = 0.0001	0.01 (SE 0.01), p = 0.00004	0.02 (SE 0.01), p = 0.0001
Models including information from initial triage scores
Net reclassification improvement (NRI)	0.23 (SE 0.03), p = 0.0001	0.10 (SE 0.02), p = 0.0001	0.06 (SE 0.01), p = 0.0001
Integrated discrimination improvement (IDI)	0.05 (SE 0.01), p = 0.0001	0.02 (SE 0.01), p = 0.0001	0.01 (SE 0.01), p = 0.0001

Initial clinical model includes age, gender, main presenting symptom and vital signs (i.e., heart rate, respiratory rate, blood pressure, temperature, consciousness); full clinical model includes age, gender, comorbidities, main presenting symptom, main diagnosis and vital signs; multimarker model includes ProADM, procalcitonin, copeptin; p value refers to comparison of combined model with the clinical model

ProADM pro-adrenomedullin, ICU intensive care unit, ED emergency department, SE standard error