Table 1.
oPOSSUM 3.0 results for LPS-induced genes suppressed, not suppressed or partially suppressed by F. tularenesis
| All LPS-induced genes | Genes suppressed | Genes not suppressed | Genes partially suppressed | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TF | Family | Z-score | Fischer score | q-value | Z-score | Fisher score | q-value | Z-score | Fisher score | q-value | Z-score | Fisher score | q-value |
| AP1 | Leucine Zipper | 5.492 | 49.37 | 0.0004501 | |||||||||
| Ar | Hormone-nuclear Receptor | 9.599 | 8.988 | 0 | 7.618 | 7.526 | 5.36E-10 | ||||||
| ARID3A | Arid | 18.069 | 53.054 | 0 | 20.009 | 38.878 | 0 | 6.948 | 15.813 | 2.65E-07 | |||
| CEBPA | Leucine Zipper | 17.508 | 56.795 | 0 | 7.313 | 24.871 | 5.02E-09 | 7.727 | 19.6 | 1.11E-09 | |||
| Egr1 | BetaBetaAlph-zinc finger | 9.242 | 35.76 | 0 | 10.597 | 15.075 | 0 | ||||||
| FOXA1 | Forkhead | 9.272 | 46.98 | 0 | 9.751 | 29.455 | 0 | ||||||
| Foxa2 | Forkhead | 7.135 | 47.333 | 1.38E-08 | 12.479 | 41.802 | 0 | ||||||
| FOXD1 | Forkhead | 13.729 | 53.842 | 0 | 14.463 | 39.964 | 0 | ||||||
| Foxd3 | Forkhead | 17.779 | 49.257 | 0 | 15.734 | 40.563 | 0 | ||||||
| FOXF2 | Forkhead | 6.49 | 20.958 | 1.10E-06 | 7.19 | 21.679 | 1.20E-08 | ||||||
| FOXI2 | Forkhead | 14.135 | 36.86 | 0 | 16.058 | 36.651 | 0 | ||||||
| FOXO3 | Forkhead | 14.321 | 50.651 | 0 | 12.83 | 37.983 | 0 | 5.324 | 14.497 | 0.003402 | |||
| Foxq1 | Forkhead | 10.523 | 44.105 | 0 | 11.804 | 42.968 | 0 | ||||||
| Gatal | GATA | 9.843 | 45.572 | 0 | 6.597 | 31.379 | 7.22E-07 | 0.013187 | |||||
| Gfi | BetaBetaAlpha-zinc finger | 12.107 | 48.885 | 0 | 7.9 | 15.946 | 3.61E-10 | ||||||
| HLF | Leucine Zipper | 11.858 | 24.551 | 0 | |||||||||
| HOXAS | Homeo | 19.619 | 55.444 | 0 | 20.668 | 35.237 | 0 | 5.306 | 16.325 | 0.003501 | |||
| IRFI | IRF | 16.593 | 37.42 | 0 | 11.588 | 30.497 | 0 | 6.563 | 11.061 | 2.93E-06 | |||
| IRF2 | IRF | 10.478 | 10.828 | 0 | |||||||||
| Lhx3 | Homeo | 10.204 | 21.206 | 0 | 15.823 | 27.512 | 0 | ||||||
| MEF2A | MADS | 11.261 | 28.869 | 0 | 5.667 | 22.212 | 0.000234 | 5.164 | 9.596 | 0.007108 | |||
| MIZF | BetaBetaAlpha-zinc finger | 5.96 | 15.897 | 3.14E-05 | 8.243 | 20.427 | 4.82E-12 | ||||||
| NFATC2 | Rel | 7.841 | 54.491 | 6.71E-11 | 7.61 | 8.397 | 1.70E-09 | ||||||
| NFE2L2 | Leucine Zipper | 5.901 | 27.696 | 4.39E-05 | |||||||||
| NFIL3 | Leucine Zipper | 14.295 | 38.826 | 0 | 9.437 | 35.141 | 0 | ||||||
| NF-kappaB | Rel | 13.665 | 56.778 | 0 | 39.032 | 14.744 | 0 | 5.492 | 16.553 | 0.001656 | |||
| NFKB1 | Rel | 5.708 | 14.056 | 0.0001325 | |||||||||
| Nkx2-5 | Homeo | 22.118 | 58.941 | 0 | 26.88 | 44.266 | 0 | ||||||
| NKX3-1 | Homeo | 15.244 | 41.36 | 0 | 17.48 | 37.027 | 0 | ||||||
| Nobox | Homeo | 9.798 | 46.489 | 0 | 12.618 | 43.858 | 0 | ||||||
| Pax6 | Homeo | 6.502 | 10.168 | 1.04E-06 | 10.422 | 16.405 | 0 | ||||||
| Pdx1 | Homeo | 13.632 | 51.723 | 0 | 19.67 | 41.917 | 0 | ||||||
| PLAG1 | BetaBetaAlpha-zinc finger | 7.702 | 14.764 | 1.95E-10 | |||||||||
| Pou5fl | Homeo | 6.767 | 12.53 | 1.77E-07 | |||||||||
| Pnx2 | Homeo | 14.121 | 49.554 | 0 | 18.221 | 38.381 | 0 | ||||||
| REL | Rel | 11.771 | 55.54 | 0 | 30.632 | 10.072 | 0 | 5.323 | 11.424 | 0.003402 | |||
| RELA | Rel | 13.26 | 45.068 | 0 | 42.057 | 16.996 | 0 | 5.945 | 9.196 | 0.000138 | |||
| Sox5 | High Mobility Group | 15.026 | 49.598 | 0 | 18.695 | 46.646 | 0 | 5.001 | 15.29 | 0.013577 | |||
| SOX9 | High Mobility Group | 8.54 | 45.725 | 0 | 12.388 | 30.748 | 0 | ||||||
| SPIB | Ets | 5.794 | 74.595 | 8.15E-05 | 9.177 | 7.168 | 0 | ||||||
| SRF | MADS | 8.106 | 8.71 | 6.92E-12 | |||||||||
| STAT1 | Stat | 6.86 | 30.655 | 9.53E-08 | 20.574 | 7.325 | 0 | ||||||
| TBP | TATA-binding | 14.562 | 52.455 | 0 | 11.841 | 43.297 | 0 | 7.908 | 14.859 | 3.61E-10 | |||
Background: All 29,347 genes in oPOSSUM database, Conservation: 0.4, Matric Threshold: 85 %, Search region +/−2000 bp. Q-value represents FDR adjusted p-values