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. 2015 Sep;10(9):1498–1506. doi: 10.4103/1673-5374.165523

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Copyright: © Neural Regeneration Research

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Morphology of distal nerve anastomotic sites at 8 weeks after transplantation of CEANA loaded with neurotrophic factors-transfected BMSCs shown on transverse sections (toluidine blue staining, optical microscope, × 40).

(A1, A2) CEANA + BDNF/BMSCs group; (B1, B2) CEANA + CNTF/BMSCs group; (C1, C2) CEANA + BDNF + CNTF/BMSCs group. In the CEANA + BDNF + CNTF/BMSCs group, there was a large number of large-sized regenerated nerve fibers with thick myelin sheath. The number of myelinated nerve fibers and myelin thickness were greater in the CEANA + BDNF + CNTF/BMSCs group than in the CEANA + BDNF/BMSCs and CEANA + CNTF/BMSCs groups. CEANA: Chemically extracted acellular nerve allografts; BDNF: brain-derived neurotrophic factor; CNTF: ciliary neurotrophic factor; BMSCs: bone marrow mesenchymal stem cells.