Table 2.
Contact residues in the RF61 Fab-IgG1 Fc interaction
| CDR residue (Kabat numbering) | Fc contact | Fc chain | Types of contact | |
|---|---|---|---|---|
| H1 | ||||
| Arg31 | Gly420 | A | HB | V1 |
| Val422 | A | V5 | ||
| Ser442 | A | HB | V2 | |
| Tyr35 | Asp356 | B | HB | V5 |
| H2 | ||||
| Tyr52 | Lys439 | A | V8 | |
| Ser440 | A | HB | V1 | |
| Tyr53 | Gln438 | A | HB | V6 |
| Ser440 | A | HB | V3 | |
| Ser54 | Gln438 | A | HB | V1 |
| H3 | ||||
| Asp98 | Arg355 | B | SB | V2 |
| Tyr100 | Thr350 | A | HB | V2 |
| Asp356 | B | V6 | ||
| Lys439 | A | V2 | ||
| Ser440 | A | HB | V3 | |
| Leu441 | A | V2 | ||
| Thr100a | Arg355 | B | HB | V2 |
| Asp100c | Arg355 | B | SB | V1 |
| L1 | ||||
| Ser30 | Gln418 | B | HB | V2 |
| Asn31 | Lys414 | B | HB | V3 |
| Tyr34 | Arg355 | B | HB | V3 |
| L2 | ||||
| None | ||||
| L3 | ||||
| Trp91 | Thr359 | B | V6 | |
| Asp93 | Lys414 | B | V3 | |
HB, hydrogen bond; SB, salt-bridge; Vn, number of van der Waals contacts.