Table 4.

Effects of anti-β₂GPI and aCL human monoclonal antibodies (mAb, 25 µg/ml) on basal and GnRH-induced hCG production^*

	Anti-β2GPI			aCL
	Control	mAb TM1G2	mAb TM1B9	Control (serum-free)	mAb 519	mAb 57
Basal	10 ± 2	8.5 ± 2	11 ± 3	14 ± 3	10 ± 2	15 ± 5
GnRH, 10−7M	18 ± 7‡	10 ± 2.9†	23 ± 4	25 ± 4‡	11 ± 4†	27 ± 3

^*Values are mIU/ml hCG (mean ± SD of triplicate experiments). Anti-β₂GPI = anti–β₂-glycoprotein I; aCL = anticardiolipin (see Table 3 for other definitions).

^†P < 0.05 versus trophoblast cells in control medium in the presence of the irrelevant mAb.

^‡P < 0.02 versus untreated cells.