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. Author manuscript; available in PMC: 2015 Oct 29.
Published in final edited form as: Horm Mol Biol Clin Investig. 2015 Aug 1;23(2):39–46. doi: 10.1515/hmbci-2015-0019

Figure 1. The RBP4/STRA6 pathway.

Figure 1

STRA6 binds extracellular holo-RBP4 and mediates transport of retinol to receptor-associated cellular retinol-binding protein 1 (CRBP1). Retinol transfer triggers phosphorylation of STRA6, resulting in recruitment and activation of JAK2 and its associated transcription factors STAT3/STAT5. Activated STAT translocates to the nucleus where it induces target gene expression. Upon binding retinol, CRBP1 dissociates from STRA6 and delivers retinol to lecithin:retinol acyl transferase (LRAT) which catalyzes the formation of retinylesters. STRA6 (GeneID 64220RBP) was drawn in accordance with prediction of a model generated by the software http://bp.nuap.nagoya-u.ac.jp/sosui.