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. 2015 Aug 17;2(3):214–232. doi: 10.3390/jcdd2030214

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© 2015 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Characterization of VIC phenotypes in diseased mitral valves from 12 month old Fbn1^C1039/+ mice. Pentachrome staining to show extracellular matrix composition and organization in 12 month wild type (Fbn1^+/+ mice) (A) and Fbn1^C1039/+ (B) mice. (C–H) Immunohistochemistry to detect expression of smooth muscle α-actin (SMA) with Periostin (C,D), Twist1 (E,F) and Vimentin (G,H) in cells within the mitral valve leaflet of wild type (C,E,G) and Fbn1^C1039/+ (D,F,H) mice. Arrows indicate SMA expression (red) and arrowheads indicate Periostin (C,D), Twist1 (E,F) and Vimentin (G,H) shown in green. mmv, mural mitral valve.