Table 4.
Accuracy indices of the pLDH band compared with expert microscopy and PCR to detect P. falciparum
| Carestart™ | First Response® | Parascreen® | SD Bioline® | |
|---|---|---|---|---|
| Expert microscopy as the reference | ||||
| TP, FP | 7, 6 | 6, 7 | 6, 5 | 6, 4 |
| FN, TN | 17, 904 | 18, 903 | 18, 905 | 18, 906 |
| Sensitivity (95 % CI) | 29.2 (13.4–51.2) | 25 (10.6–47.1) | 25 (10.6–47.1) | 25 (10.6–47.1) |
| Specificity (95 % CI) | 99.3 (98.5–99.7) | 99.2 (98.3–99.7) | 99.5 (98.6–99.8) | 99.6 (98.8–99.9) |
| PPV (95 % CI) | 53.8 (26.1–79.6) | 46.1 (20.4–73.9) | 54.5 (24.6–81.9) | 60 (27.4–86.3) |
| NPV (95 % CI) | 98.2 (96.9–98.8) | 98.0 (96.7–98.8) | 98 (96.9–98.8) | 98.1 (96.9–98.8) |
| LR positive (95 % CI) | 44.2 (16.1–121.7) | 32.5 (11.8–89.4) | 45.5 (14.9–138.8) | 56.9 (17.2–188.5) |
| LR negative (95 % CI) | 0.71 (0.55–0.92) | 0.76 (0.60–0.95) | 0.75 (0.60–0.95) | 0.75 (0.60–0.95) |
| DOR (95 % CI) | 62 (16.5–239.0) | 43 (11.4–162.7) | 60.3 (14.5–257.2) | 75.5 (16.9–356.3) |
| PCR as the reference | ||||
| TP, FP | 7, 6 | 8, 5 | 6, 5 | 7, 3 |
| FN, TN | 25, 896 | 24, 897 | 26, 897 | 25, 899 |
| Sensitivity (95 % CI) | 21.9 (9.9–40.4) | 25 (12.1–43.8) | 18.8 (7.9–37.0) | 21.9 (9.9–40.4) |
| Specificity (95 % CI) | 99.3 (98.4–99.7) | 99.4 (98.6–99.8) | 99.4 (98.6–99.8) | 99.7 (98.9–99.9) |
| PPV (95 % CI) | 53.8 (26.1–79.6) | 61.5 (32.2–84.9) | 54.5 (24.6–81.9) | 70 (35.4–91.9) |
| NPV (95 % CI) | 97.3 (96.0–98.2) | 97.4 (96.1–98.3) | 97.2 (95.8–98.1) | 97.3 (96.0–98.2) |
| LR positive (95 % CI) | 32.9 (11.7–92.3) | 45.1 (15.6–130.2) | 33.8 (10.9–105.1) | 65.8 (17.8–242.7) |
| LR negative (95 % CI) | 0.79 (0.65–0.94) | 0.75 (0.62–0.92) | 0.82 (0.69–0.97) | 0.78 (0.65–0.94) |
| DOR (95 % CI) | 41.8 (11.5–154.1) | 59.8 (16.2–230.7) | 41.4 (10.3–169.9) | 83.9 (18.0–439.7) |
TP true positive, FP false positive, FN false negative, TN true negative, CI confidence interval, PPV positive predictive value, NPV negative predictive value, LR likelihood ratio, DOR diagnostic odds ratio