Table 4.
APOL1 risk allele associations with HIVAN, HIV-associated FSGS, and HIV-negative FSGS (primary FSGS)
| No. of Risk Alleles | HIV-Positive CKD Patient Groups (n=51) versus HIV-Positive Controls (n=54) | Primary FSGS (n=9) versus Population Controls (n=54) | All FSGS (n=22) versus All Controls (n=108) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HIVAN (n=38) | HIV-Positive FSGS (n=13) | Primary FSGS (n=9) | HIV-Positive FSGS (n=13) and Primary FSGS (n=9) | ||||||
| OR (95% CI) | P Value | Adjusted P Valuea | OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | |
| 1 versus 0 | 5.49 (0.87 to 61.14) | 0.05 | 0.13 | 0.63 (0.10 to 2.98) | 0.74 | 1.3 (0.18 to 7.42) | >0.99 | 0.86 (0.25 to 2.64) | >0.99 |
| 2 versus 0 | 200.87 (27.62 to 3119.17) | 1.5×10−14 | 1.9×10−3 | 1.85 (0.03 to 39.57) | 0.53 | 6.70 (0.08 to 577.00) | 0.26 | 3.27 (0.25 to 31.46) | 0.22 |
| 2 versus 1 | 40.50 (7.09 to 446.94) | 8.7×10−08 | 1.8×10−4 | 2.82 (0.04 to 73.20) | 0.44 | 5.0 (0.05 to 467.90) | 0.34 | 3.74 (0.26 to 40.67) | 0.20 |
| 2 versus 1 or 0 recessive model | 89.1 (17.68 to 911.72) | 1.2×10−14 | 1.5×10−5 | 2.13 (0.03 to 44.30) | 0.48 | 6.30 (0.04 to 248.70) | 0.26 | 3.45 (0.27 to 32.23) | 0.20 |
ORs (95% CIs) are shown for the association between APOL1 risk alleles and particular glomerular diseases. P values are from Fisher’s exact test unless otherwise noted.
a
Analyses were adjusted for age, sex, and ancestry.