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. 2015 Mar 18;26(11):2659–2668. doi: 10.1681/ASN.2014050485

Figure 1.

Figure 1.

Genetic deficiency of AZGP1 exacerbates progression of renal fibrosis in UUO and AAN. (A) Representative images of hematoxylin/eosin staining of AZGP1+/− and AZGP1−/− kidney sections after 2 weeks of UUO. (B) Representative images showing LTL staining as a marker of intact proximal tubular brush border in UUO kidneys. Representative images of Picrosirius Red staining in (C) bright-field and (D) polarized light at 4 weeks of AAN. (E) Quantification of the LTL-positive area in the outer medulla region of UUO and AAN kidneys. (F) Quantification of birefringent collagen fibers in Picrosirius Red–stained kidney sections after UUO and AAN. UUO was evaluated for all data at 2 weeks, and AAN was evaluated for all data at 4 weeks. Values are given as means±SEMs (n=8 for E and F). Original magnifications, ×200 in A, C, and D; ×100 in B. *P<0.05.