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. 2015 Mar 18;26(11):2647–2658. doi: 10.1681/ASN.2014080741

Figure 8.

Figure 8.

Increased RIP1 or RIP3 expression in PTCs enhances their susceptibility to cisplatin-induced necroptosis. (A) PTCs from male C57BL/6 mice were infected with or without Flag-RIP3–expressing lentivirus for 36 hours and then treated with different does of cisplatin for 12 hours. The PI-positive cells (left panel) and the RIP3 levels (right panel) are shown (n=4). (B) PTCs were infected with different doses of Flag-RIP3–expressing lentivirus for 36 hours and then treated with 50 µM cisplatin for 12 hours. The PI-positive cells (top panel) and the RIP3 levels (bottom panel) are shown (n=4). (C and D) As in A and B except that Myc-RIP1 expression lentivirus was used (n=4). *P<0.05 and **P<0.01 versus 0 µM cisplatin group; #P<0.05 and ##P<0.01 versus vector group.