Table 4.
Risk of various outcomes by baseline VEGF level
| Models | Unadjusted | Model 1 | Model 2 | Model 3 | Model 4 | Model 5 |
|---|---|---|---|---|---|---|
| All-cause mortality | ||||||
| Quartile 1 (<160 pg/ml) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) |
| Quartile 2 (160–290 pg/ml) | 1.04 (0.68–1.59) | 1.06 (0.69–1.62) | 1.08 (0.70–1.68) | 0.94 (0.60–1.48) | 0.96 (0.60–1.53) | 0.92 (0.57–1.49) |
| Quartile 3 (291–507 pg/ml) | 1.11 (0.90–1.37) | 1.10 (0.90–1.36) | 1.18 (0.95–1.46) | 1.19 (0.96–1.48) | 1.13 (0.90–1.42) | 1.13 (0.90–1.42) |
| Quartile 4 (≥508pg/ml) | 1.20 (1.06–1.37) | 1.22 (1.07–1.39) | 1.25 (1.09–1.45) | 1.24 (1.04–1.43) | 1.14 (0.98–1.32) | 1.18 (1.01–1.37) |
| For each 100 pg/ml increase | 1.04 (1.02–1.06) | 1.04 (1.02–1.06) | 1.04 (1.02–1.07) | 1.04 (1.01–1.06) | 1.00 (0.97–1.03) | 1.00 (0.97–1.04) |
| Cardiovascular events | ||||||
| Quartile 1 (<160 pg/ml) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) | 1.0 (Ref) |
| Quartile 2 (160–290 pg/ml) | 0.97 (0.72–1.31) | 0.95 (0.70–1.29) | 0.93 (0.69–1.27) | 1.01 (0.74–1.37) | 0.99 (0.72–1.36) | 1.05 (0.76–1.44) |
| Quartile 3 (291–507 pg/ml) | 1.09 (0.94–1.26) | 1.08 (0.93–1.25) | 1.12 (0.87–1.30) | 1.13 (0.98–1.31) | 1.13 (0.97–1.31) | 1.14 (0.98–1.34) |
| Quartile 4 (≥508pg/ml) | 1.11 (1.01–1.22) | 1.11 (1.01–1.22) | 1.15 (1.04–1.26) | 1.23 (1.13–1.30) | 1.12 (1.02–1.24) | 1.14 (1.03–1.27) |
| For each 100 pg/ml increase | 1.03 (1.01–1.05) | 1.02 (1.00–1.04) | 1.04 (1.02–1.06) | 1.05 (1.02–1.06) | 1.03 (1.01–1.05) | 1.03 (1.01–1.05) |
Model 1 adjusted for age and sex. Model 2 adjusted for covariates in model 1 plus risk factors, including diabetes, hypertension, dyslipidemia, obesity, smoking, previous coronary artery disease, previous stroke, and CKD stage. Model 3 adjusted for covariates in model 2 plus current medications, including RAS blockers, calcium channel blockers, β-blockers, mineralocorticoid receptor antagonists, lipid-lowering agents, diuretics, and antiplatelet agents. Model 4 adjusted for covariates in model 3 plus laboratory data, including hemoglobin, serum albumin, serum calcium, phosphorus, serum C-reactive protein, HbA1c, LDL cholesterol, HDL cholesterol, and triglycerides. Model 5 adjusted for covariates in model 4 plus BNP. Ref, reference.