Table 4.

Diagnostic performances of the urinary biomarkers in detecting any type of AR, TCMR, all ABMR (i.e., ABMR with or without associated tubulointerstitial inflammation), mixed rejection (i.e., ABMR with i+t≠0), and pure ABMR (i.e., ABMR with i+t=0)

Biomarker	ROC–Based Discrimination Measures				PPV	NPV
	AUC (95% CI)a	AUC P Value	Sensitivity	Specificity
AR
CXCL10	74.4 (68.1 to 80.8)	<0.001	59.0	83.3	57.5	84.1
CXCL10:Cr	76.1 (70.0 to 82.2)	<0.001	65.4	76.4	51.5	85.2
CXCL9	71.6 (64.9 to 78.2)	<0.001	58.4	84.5	59.2	84.1
CXCL9:Cr	71.2 (63.7 to 78.7)	<0.001	63.6	78.0	52.7	84.8
TCMR
CXCL10	72.6 (56.9 to 88.2)	<0.01	60.0	79.3	12.5	97.6
CXCL10:Cr	79.9 (67.7 to 92.2)	<0.001	70.0	76.4	12.7	98.1
CXCL9	85.7 (73.8 to 97.7)	<0.001	80.0	87.0	23.5	98.9
CXCL9:Cr	90.5 (84.0 to 97.1)	<0.001	90.0	84.0	22.0	99.4
All ABMR
CXCL10	74.7 (68.0 to 81.4)	<0.001	60.3	83.3	54.7	86.2
CXCL10:Cr	75.5 (69.0 to 82.1)	<0.001	64.7	77.3	48.9	86.7
CXCL9	69.4 (62.3 to 76.6)	<0.001	55.2	84.5	54.4	84.9
CXCL9:Cr	68.3 (60.0 to 76.5)	<0.001	59.7	78.0	47.6	85.2
Mixed rejection
CXCL10	80.0 (71.3 to 88.7)	<0.001	74.2	83.3	40.4	95.5
CXCL10:Cr	81.9 (73.9 to 89.8)	<0.001	77.4	78.3	35.3	95.8
CXCL9	78.0 (68.2 to 87.8)	<0.001	71.0	84.5	41.5	94.9
CXCL9:Cr	77.8 (66.8 to 88.8)	<0.001	71.0	84.5	41.5	94.9
Pure ABMR
CXCL10	70.2 (61.5 to 79.0)	<0.001	73.0	61.6	25.7	92.6
CXCL10:Cr	70.2 (61.4 to 79.0)	<0.001	67.6	62.1	24.5	91.3
CXCL9	62.1 (53.0 to 71.2)	0.002	50.0	74.0	25.7	89.2
CXCL9:Cr	60.1 (49.1 to 71.1)	0.03	50.0	78.0	29.0	89.7

The C statistics, sensitivity, specificity, positive predictive values (PPVs), and NPVs are shown.

^a95% CIs were generated by 2000 stratified bootstrap replicates.