Fig. 3.

Drug network analysis. Sub-networks connected to genome-wide ranked lists of genes sorted according to their differential expression in PD: decreasing order in (a) and increasing order in (b), once they are integrated in the drug network as described in Iorio et al. [31]. For clarity we included only the first 35 most similar (resp. “anti-similar”) to PD drugs. Edge thickness is inversely proportional to the distance between the drugs and the conditions. Several antipsychotic drugs (community n. 100 in a) elicit a transcriptional response similar to PD while compounds used for PD treatment elicit an “anti-similar” to PD response (bold in b). The complete list is available in Additional file 14