Table 2.
Identification of tissue-enrichment terms and biological processes associated with selected genes dysregulated in blood of PD patients versus controls
| Category | Term | Count | Percent | P-Value | Benjamini |
|---|---|---|---|---|---|
| a | |||||
| UP TISSUE | Brain | 141 | 50.00 | 7.4E-3 | 7.1E-1 |
| UP TISSUE | Testis | 70 | 24.08 | 1.9E-2 | 8.0E-1 |
| UP TISSUE | Epithelium | 59 | 20.09 | 3.2E-2 | 8.4E-1 |
| UP TISSUE | Lymphoma | 4 | 1.04 | 6.1E-2 | 9.3E-1 |
| UP TISSUE | Testicle | 3 | 1.01 | 7.4E-2 | 9.2E-1 |
| b | |||||
| GOTERM_BP_FAT | ncRNA processing | 10 | 3.05 | 4.2E-3 | 1.0E0 |
| GOTERM_BP_FAT | regulation of gene expression, epigenetic | 6 | 2.01 | 1.1E-2 | 1.0E0 |
| GOTERM_BP_FAT | lymphocyte activation | 10 | 3.05 | 1.3E-2 | 1.0E0 |
| GOTERM_BP_FAT | lipid homeostasis | 5 | 1.08 | 1.5E-2 | 1.0E0 |
| GOTERM_BP_FAT | chromatin assembly or disassembly | 7 | 2.05 | 1.7E-2 | 9.9E-1 |
| GOTERM_BP_FAT | midbrain development | 3 | 1.01 | 2.0E-2 | 9.9E-1 |
| GOTERM_BP_FAT | chemical homeostasis | 17 | 6.00 | 2.9E-2 | 1.0E0 |
| GOTERM_BP_FAT | negative regulation of protein kinase cascade | 4 | 1.04 | 3.0E-2 | 1.0E0 |
| GOTERM_BP_FAT | ncRNA metabolic process | 9 | 3.02 | 3.5E-2 | 1.0E0 |
| GOTERM_BP_FAT | regulation of action potential | 5 | 1.08 | 3.8E-2 | 1.0E0 |
| GOTERM_BP_FAT | leukocyte activation | 10 | 3.05 | 3.9E-2 | 1.0E0 |
| GOTERM_BP_FAT | cell activation | 11 | 3.09 | 4.2E-2 | 1.0E0 |
a)Tissue enrichment analysis. Count: number of genes involved in the term; %: percentage of involved genes/total genes; P-Value: modified fisher exact P-value, EASE Score; Benjamini: adjusted P-value using Benjamini-Hochberg procedure. b)Biological processes identified by GO annotations (DAVID)