Figure 1.
Target-mediated drug disposition (TMDD) model schematic describing lampalizumab ocular and systemic pharmacokinetics. Cunbound, RVITR, and R-C compartments represent the free drug, free target, and drug–target complexes in the vitreous humor, respectively. CAQ and RAQ represent total drug and total target in the aqueous humor, respectively. CSER represents total drug in serum. kout and k represent ocular and systemic elimination constants of drug. koutT and koutC represent ocular elimination rate of target and complex, respectively. kinT represents the combined rate of synthesis and/or influx of target into the eye. Kss represents the quasi-steady-state equilibrium constant. λAQ and λTAQ represent vitreous-aqueous humor partition coefficients of drug and target, respectively. Square boxes represent total (free and bound) analytes. Circle boxes represent analytes in either free or complex form. Dotted boxes represent hypothetical compartments, and solid boxes represent those with measured data.