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. 2015 Oct 8;4(10):595–604. doi: 10.1002/psp4.12031

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© 2015 The Authors. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Impact of age and sex on serum and vitreous humor exposures. The black boxes illustrate the 90% prediction interval of individual exposures in the analysis population. The blue boxes correspond to the predictions of exposure for typical patients (80-year-old males) with the covariate values equal to 5^th and 95^th percentiles of the covariate distribution in the analysis population. AUC, area under the serum concentration time curve; C_max, maximum concentration; C_trough, minimum concentration; PI, prediction interval.