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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Curr Opin Virol. 2014 Sep 28;9:45–52. doi: 10.1016/j.coviro.2014.09.005

Figure 2. Lipids in HCV maturation.

Figure 2

The first step in HCV assembly often takes place on LDs. HCV core localizes to LDs that are in proximity to ER-associated virus replication factory. Following replication, HCV NS5A brings the nascent RNA to LDs via interaction with DGAT1 and core proteins, thus initiating virus assembly [90]. The two enzymes, ACS and ACAT, are crucial for LDs biogenesis and facilitate HCV assembly [84]. Virus particles maturation, in the form of LVP, requires cholesterol and sphingolipids, which may be provided by OSBP and CERT, two PI4P effector proteins [98]. E1/E2: HCV glycoproteins; LuLD: luminal LDs; VLDL: very low density lipoprotein; LVP: lipo-viro-particle.