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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Curr Opin Virol. 2014 Sep 28;9:45–52. doi: 10.1016/j.coviro.2014.09.005

Table 1.

Host factors and related lipids in RNA virus replication.

PROTEIN LOCATION FUNCTION REFERENCES
FASN Cytosol Fatty acid synthesis for membrane expansion in virus replication factory. [23,78]
PI4KIIIα ER PI4P synthesis; required for membranous web vesicles formation [39,45]
PI4KIIIβ Golgi PI4P synthesis and stimulation of viral 3DPol in enteroviruses. [101,102]
OSBP ER and Golgi Transports cholesterol to the HCV replication complex. [67]
CERT ER and Golgi Transports ceramide from ER to Golgi for sphingomyelin biosynthesis; required for virus production. [103]
DHCR24 ER Contributes to cholesterol synthesis; required for HCV genome replication. [65]
DGAT1 ER Recruits HCV core and NS5A to lipid droplets: required for virus assembly. [79,90,104]
ACS ER Fatty acyl-CoA synthesis for incorporation into triglycerides and cholesterol esters in lipid droplets; required for virus production. [84]
ACAT ER Conversion of cholesterol to cholesterol esters in lipid droplets; required for virus production. [84]