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Co-stimulation of B cells by LPS and CD154 hampers CSR and plasma cell differentiation (flow cytometry analysis). (a, b) CSR to IgG1 (a) and formation of B220loCD138hi plasma cells (b) in B cell cultures after stimulation with LPS (3 μg/ml), CD154 (3 unit/ml) or both plus IL-4 for 4 d. Data are representative of three independent experiments.
