Table 3.
Pretreatment | Treatment (p.o.) | Dose (mg/kg) | UI (mm) | Increase lesion (%) |
---|---|---|---|---|
Saline | Saline | 10 | 17 ± 5,5 | - |
L-NAME (70 mg/Kg) | Saline | 10 | 59 ± 15* | 247 |
L-NAME (70 mg/Kg) | Sa-FRF | 100 | 39 ± 5,4* | 129 |
L-NAME (70 mg/Kg) | Sa-FDF | 22 ± 1,9 | 29 | |
Saline | Saline | 10 | 16 ± 5,7 | - |
L-NAME (70 mg/Kg) | Saline | 10 | 60 ± 14** | 275 |
L-NAME (70 mg/Kg) | Sb-FRF | 100 | 32 ± 6,3* | 100 |
L-NAME (70 mg/Kg) | Sb-FDF | 100 | 20 ± 3,5 | 25 |
ANOVA followed by Dunnett’s test.*p < 0.05, **p < 0.01. Data are presented as mean ± S.D (n = 5-7)