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. 2015 Oct 29;10(10):e0141572. doi: 10.1371/journal.pone.0141572

Fig 4. L-citrulline increases the mRNA expression of iNOS and exogenous NO prevents SF-induced muscle wasting.

Fig 4

mRNA expression of eNOS (A); nNOS (B) and; iNOS (C) for DM and after 24 h in serum free (SF) media treated with vehicle, 2.5 mM L-arginine (ARG) or 2.5 mM L-citrulline (CIT). iNOS expression (D) after 5 h incubation in HEPES buffered saline (HBS). Myotube diameter (E) and representative images (20× objective) (F) after 48 h incubation in serum free media (SF). Cells were treated with vehicle (PBS) or 0.2 mM of the NO donor sodium nitroprusside (SNP). Values are means ± SE, n = 4–6 per group. Comparisons were made using a one-way ANOVA with Tukey’s post hoc test. Different letters denote significant differences (P<0.05) between groups, where a>b>c.