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. 2015 Oct 29;10(10):e0141676. doi: 10.1371/journal.pone.0141676

Fig 1. The 5'-terminal region of p53 mRNA and complementary antisense oligonucleotides.

Fig 1

(A) The antisense oligomer binding sites are displayed in this secondary structure model of the 5'-terminal region of p53 mRNA [19, 27]. (B) Energy requirements for RNA target-oligomer hybrid formation calculated by the OligoWalk function in the RNAstructure 5.6 program [30]. Overall ΔG—the target-oligomer binding, including breaking RNA target structure and oligomer self-structure; duplex ΔG—the target-oligomer binding from unstructured states; break target ΔG—the energy penalty due to breaking of intramolecular RNA target base pairs when the oligomer is bound.