Table 2. Fangchinoline induced cell cycle arrest at G0/G1 phase and apoptosis in PC-3 cells.
| Dose of fangchinoline (μM) | Percentage (%) of cells in G0/G1 phase | Percentage (%) of cells in G2/M phase | Percentage (%) of cells in S phase | Percentage (%) of apoptotic cells (Annexin+/PI+) |
|---|---|---|---|---|
| 0 | 56.52±1.15 | 10.29±0.98* | 33.20±2.00 | 4.21±0.93* |
| 5 | 60.17±1.49 | 11.21±2.45* | 28.62±2.31 | 6.74±1.14* |
| 8 | 64.25±1.57* | 11.99±2.23* | 23.76±2.77 | 10.79±0.51* |
| 12 | 63.03±0.73* | 11.59±1.99* | 25.37±1.75* | 13.53±0.19* |
| 18 | 67.63±3.34* | 8.88±2.91 | 23.48±2.14* | 28.10±5.93* |
| 27 | 75.16±1.95* | 8.65±1.81 | 16.19±0.63* | 37.52±4.04* |
| 40 | 80.14±1.55* | 7.99±1.43 | 11.88±0.56* | 49.77±2.23* |
*P<0.05 compared with control (dose at 0 μM).