Table I.
SM-modulated changes in gene expression of CAM- and ECM-related molecules.
| Gene | FC | FR | Unigene | Accession |
|---|---|---|---|---|
| CLEC3B | 0.43 | −2.33 | Hs.476092 | NM_003278 |
| CNTN1 | 0.33 | −2.99 | Hs.143434 | NM_001843 |
| COL11A1 | 2.28 | 2.28 | Hs.523446 | NM_080629 |
| COL14A1 | 0.43 | −2.34 | Hs.409662 | NM_021110 |
| COL16A1 | 0.47 | −2.14 | Hs.368921 | NM_001856 |
| COL1A1 | 0.49 | −2.03 | Hs.172928 | NM_000088 |
| COL5A1 | 0.49 | −2.04 | Hs.210283 | NM_000093 |
| CTGF | 0.47 | −2.11 | Hs.591346 | NM_001901 |
| CTNNA1 | 0.10 | −10.65 | Hs.534797 | NM_001903 |
| CTNND2 | 2.16 | 2.16 | Hs.314543 | NM_001332 |
| ITGB2 | 0.43 | −2.34 | Hs.375957 | NM_000211 |
| KAL1 | 0.48 | −2.08 | Hs.521869 | NM_000216 |
| LAMA3 | 0.41 | −2.46 | Hs.436367 | NM_000227 |
| MMP2 | 2.70 | 2.70 | Hs.513617 | NM_004530 |
| MMP3 | 6.37 | 6.37 | Hs.375129 | NM_002422 |
| MMP7 | 0.41 | 2.44 | Hs.2256 | NM_002423 |
| MMP12 | 2.74 | 2.74 | Hs.1695 | NM_002426 |
| MMP13 | 0.47 | −2.14 | Hs.2936 | NM_002427 |
| SELE | 3.49 | 3.49 | Hs.89546 | NM_000450 |
| SPARC | 0.24 | −4.16 | Hs.111779 | NM_003118 |
| TGFBI | 0.34 | −2.92 | Hs.369397 | NM_000358 |
| THBS3 | 0.38 | −2.60 | Hs.169875 | NM_007112 |
| VCAN | 0.35 | −2.82 | Hs.643801 | NM_004385 |
Gene expression was assessed using an RT2 Profiler PCR array. SM, cigarette smoke medium; FC, fold change; FR, fold regulation; RT, reverse transcription; CAMs, cell adhesion molecules; ECM, extracellular matrix; PCR, polymerase chain reaction; CLEC3B, c-type lectin domain family 3; CNTN1, contactin 1; COL1A1, collagen type I α 1; CTGF, connective tissue growth factor; CTNNA1, catenin α 1; CTNND2, catenin Δ 2; ITGB2, integrin β 2; KAL1, kallmann syndrome 1 sequence; LAMA3, laminin α 3; MMP, matrix metallopeptidase; SELE, selectin E; SPARC, secreted protein acidic, cysteine-rich; TGFB1, transforming growth factor, β-induced; THBS3, Thrombospondin 3; and VCAN, Versican.