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. 2015 Sep 29;12(5):7412–7418. doi: 10.3892/mmr.2015.4387

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Copyright: © Hou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Fig. 1 — Isoflurane suppresses proliferation in a p53-dependent manner. (A) The results of the methyl thiazolyl tetrazolium assay indicated that isoflurane inhibited the proliferation of WT NSCs in a dose-dependent manner (^**P<0.01 compared with the non-treated group; n=3). (B) A significant inhibition of proliferation was observed at all the time points (^**P<0.01 compared with the non-treated group; n=3). (C) Isoflurane fails to induce any significant cell cycle arrest in the absence of p53^−/− NE-4C cells (^*P<0.05; ^#P>0.05 compared with the non-treated group; n=3). (D) The percentage of cells in the G0/G1 phase in WT NSCs treated with the IC₅₀ concentration of isoflurane was greater compared with that in the untreated group. This did not apply for the p53^−/− NE-4C cells (^**P<0.01;^*P<0.05; ^#P>0.05 compared with the non-treated group; n=3). NSCs, neural stem cells.