Table 1. Affinity constants (K a, K d) of CT302 IgG1 determined by real-time interaction analysis.
Immobilized HA protein | K D (M) | K a (M-1S-1) | K d (S-1) |
---|---|---|---|
A/Brisbane/10/2007 | 6.06±0.03×10−10 | 2.93±0.03×105 | 1.78±0.01×10−4 |
A/Wisconsin/67/2005 | 8.55±0.74×10−9 | 2.91±0.07×105 | 2.45±0.15×10−3 |
K a, association rate constant; K d, dissociation rate constant; K D, dissociation equilibrium constant calculated based on K d/K a; M, molarity.