Table I.

Reported hyperediting and restriction activity of AID/APOBECs against HBV DNA.

Cytidine deaminases	Hyperediting activity	Dinucleotide preference	Restriction activity against HBV DNA	Reference
AID	Deaminates each viral RNA and HBV minus-strand DNA	GpC, ApC	Active	25,27
A1	Deaminates HBV minus-strand DNA	TpC	Active	19,21,25
A2	NI	NI	Not active	25
A3A	Deaminates each strand of HBV DNA	Weak bias	Active/not activea	4,17,25
A3B	Deaminates each strand of HBV DNA	GpC, ApC	Active	4,16,24–26,28,37
A3C	Deaminates HBV minus-strand DNA	No bias	Active but weak/not activea	16–18,20,26,37
A3DE	Not active	N/A	NI	17
A3F	Deaminates each strand of HBV DNA	TpC, GpC	Active	16–18,20,25,26,37
A3G	Deaminates each strand of HBV DNA	CpC	Active	16–18,20,26,37,75
A3H	Deaminates each strand of HBV DNA	TpC	NI	17,20

^aControversial experimental results exist in the article. NI, no information found; N/A, not applicable; AID, activation-induced cytidine deaminase; APOBEC, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like; HBV, hepatitis B virus.