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siRNA provides prolonged co-localization. (A and B) Prolonged siRNA co-localization within the sinus mucosa. (a) Cy3-siRNA in gel; (b) Cy3-siRNA in NPs; (c) free Cy3-siRNA; and (d) blank. (C) Measurement of sinus mucosa thickness. *P<0.05, compared with the other three control groups. Data are expressed as the mean ± standard deviation. siRNA, small interfering RNA; siNC, siRNA negative control; NPs, nanoparticles; VEGF, vascular endothelial growth factor; TCP, tissue culture plate.
