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Protection against MRSA infection by synthetic melittin. Kaplan-Meier survival curve of mice inoculated with the MRSA USA300 strain. Staphylococcus aureus USA300 (0.5×108 CFU/ml) in 0.1 ml PBS was injected i.p into CD1 male mice (n=10 per group). After 1 h, synthetic melittin (2.5 or 5 mg/kg) in 0.1 ml PBS was injected i.p. Survival was monitored every 3 h for 36 h. *P<0.001. MRSA, methicillin-resistant Staphylococcus aureus; PBS, phopshate-buffered saline; i.p, intraperitoneally.
