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. 2015 Sep 10;12(5):6501–6508. doi: 10.3892/mmr.2015.4310

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Copyright: © Shi et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of adapalene (3, 10 and 30 μM) on the expression of cyclins, CDK2 and Rb in LOVO and DLD1 cells. Western blot analysis showed that adapalene treatment significantly reduced the expression of CDK2, Rb, pho-CDK2, pho-Rb and cyclin E in LOVO and DLD1 cells. By contrast, the expression levels of cyclin D1 and cyclin B1 were not affected. The numbers in between the blots indicate the ratio between the indicated protein and GAPDH gray values. The blots were representative of experiments repeated three times. CDK, cyclin-dependent kinase; pho-Rb, phosphorylated retinoblastoma protein.