Figure 4.

Oral administration of adapalene significantly reduced tumor growth in vivo in nude mice xenografted with DLD1 cells. (A) Daily adapalene treatment (from days 1–21) dose-dependently (15, 65 and 100 mg/kg) reduced the tumor volume. (B) Significant reductions in tumor weight were observed following treatment with adapalene for 21 days at concentrations as low as 15 mg/kg compared with the control group. (C) Increases in tumor volume were significantly decreased following adapalene treatment at 15–100 mg/kg for 21 days compared with the control group. Values are expressed as the mean ± standard deviation of at least three independent experiments. ^※P<0.05 vs. control.