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. 2015 Sep 10;12(5):6501–6508. doi: 10.3892/mmr.2015.4310

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Copyright: © Shi et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Oral administration of adapalene combined with oxaliplatin significantly reduced tumor growth in vivo in nude mice xenografted with DLD1 cells. (A) Daily administration of adapalene (20 mg/kg), (oxaliplatin (40 mg/kg) or their combined treatment (from days 1–21) reduced the tumor volume. (B) A significant reduction in tumor weight was observed following combined adapalene and oxaliplatin treatment for 21 days compared with that in the control group. (C) The tumor volume significantly decreased following combined adapalene and oxaliplatin treatment for 21 days compared with that in the groups treated with either adapalene or oxaliplatin alone and that in the control group. Values are expressed as the mean ± standard deviation of at least three independent experiments ^※P<0.05 vs. control. O, oxaliplatin.