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. 2015 Aug 25;12(5):6761–6767. doi: 10.3892/mmr.2015.4247

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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lncRNA LSINCT5 knockdown by siRNA inhibits caspase-1/IL-1β signaling in BNP-treated HCM cells. (A) Silencing efficiency of LSINCT5 was determined by RT-qPCR. Representative images of (B) the relative mRNA and (C) the protein expression levels of caspase-1, -3, -7 and-8 in HCM cells treated with si-LSINCT5-2. GAPDH was used as an internal control. (D) Western blot analysis and (E) RT-qPCR analysis of the expression levels of caspase-1 and IL-1β in siRNA-LSINCT5-2 and siRNA-scramble-treated HCM cells. Results are presented as the mean ± standard deviation from three independent experiments performed in duplicate. Relative expression is expressed in arbitrary units. lncRNA, long non-coding RNAs; IL, interleukin; BNP, B-type-natriuretic peptide; siRNA, small interfering RNA; RT-qPCR, reverse transcription-quantitative polymerase chain reaction. ^*P<0.05; ^**P<0.01, compared with the control group.