Table 2.

Summary of experimentally-determined degradation kinetic time constants (k_deg).

Enzymatically-responsive hydrogel	In vitro kdeg (dry mass, with 10 nM MMP2) (x10−2; hour−1)	In vivo kdeg (fluorescence intensity) (x10−2; hour−1)
SPARC113(DL)	1.16 ± 0.03b,c	1.46 ± 0.12
SPARC118(DL)	8.77 ± 0.74a,c,2	1.44 ± 0.181
Scrambled(DL)	3.23 ± 0.13a,b,2	1.50 ± 0.241

Within degradation environment (columns), across gel type (rows):

^ap<0.05 vs. SPARC₁₁₃(DL),

^bp<0.05 vs. SPARC₁₁₈(DL),

^cp<0.05 vs. Scrambled(DL).

Within gel type (rows), across degradation environment (columns):

¹p<0.05 vs. in vitro,

²p<0.05 vs. in vivo.

n=6 (in vitro) or 16 (in vivo); mean ± standard error of the mean.