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. 2015 Oct 29;10(10):e0141549. doi: 10.1371/journal.pone.0141549

Fig 1. Dose dependent effects of esculentin-2CHa and its substituted analogues on insulin release from BRIN-BD11 cells (A, B, E, F) and mouse islets (C, D). Effects on lactate dehydrogenase (LDH) release (G) is also shown.

Fig 1

Values are mean ± SEM with n = 8. For A, B, D and F, *P < 0.05, **P < 0.01, ***P < 0.001 compared with 5.6mM glucose. For B and D, ΔP < 0.05, ΔΔP < 0.01 compared with native esculentin-2CHa. For C, *P < 0.05, **P < 0.01, ***P < 0.001 compared with 16.7 mM glucose. For E, *P < 0.05, **P < 0.01, ***P < 0.001 compared with the same concentration of glucose alone. ΔP<0.05 compared with esculentin-2CHa at the same glucose concentration. ++P < 0.01, +++P < 0.001 compared with incubation at 5.6 mM glucose for each peptide. For F, ΔΔΔP < 0.001 compared with respective incubation in the absence of the peptide. +P < 0.05, ++P < 0.01, +++P < 0.001 compared with incubation at 5.6 mM glucose in the presence of esculentin-2CHa alone.