Fig 4. Effects of [L28K]esculentin-2CHa on body weight (A), cumulative energy intake (B), non-fasting plasma glucose (C) and insulin (D) in lean and high-fat fed mice. Parameters were measured 3 days prior to, and every 72 hours during twice-daily treatment (indicated by the black bar) with saline or [L28K]esculentin-2CHa (75 nmol/kg bodyweight) for 28 days.

Values are mean ± SEM with n = 8 mice. *P < 0.05, *** P < 0.001 compared to high fat fed control. All parameters were significantly lower in lean mice than high fat fed control mice (P < 0.05 –P < 0.001).