Fig 6. Effects of [L28K]esculentin-2CHa on (A) pancreatic weight, (B) pancreatic insulin content and (C) insulin-secretory responses of islets isolated from lean and high-fat fed mice treated with saline or [L28K]esculentin-2CHa (75 nmol/kg body weight) for 28 days. Values are means ± SEM for 8 mice.

For Fig 6B, ***P < 0.001 compared with lean control, ^ΔP < 0.01 compared with high-fat control. For Fig 6C, *P < 0.05,**P < 0.01, ***P < 0.001 compared with the response of islets isolated from the same group of mice at 16.7 mM glucose; ^ΔP < 0.05, ^ΔΔP < 0.01, ^ΔΔΔP < 0.001 compared with the respective response of islets isolated from lean control. For Fig 6D, stimulation index refers to fold-increase in insulin secretion from 1.4 mM glucose to 16.7 mM glucose or from 16.7 mM glucose to that observed in the presence of each secretagogue. *P < 0.05, **P < 0.01 compared with the stimulation index of islets isolated from each group of mice at 16.7mM glucose. ^ΔP < 0.05, ^ΔΔP < 0.01 compared the stimulation index of lean control.