Table 2.

Quinine-Fab interface characteristics

	Fab 314.1	Fab 314.3
	Solvent-accessible surface area (Å2)*
Quinine total	502	509
Buried on quinine	440 (87.6%)	452 (88.8%)
Buried on H chain	154	202
Buried on L chain	127	128
Buried total on Fab	281	330
Shape complementarity index†	0.764	0.809

^*Calculated by PISA.¹⁸

^†Computed by the SC program in CCP4 suite.¹⁹