Table 3. Effect of a single preoperative dose of AZM or AMX on inflammatory mediator concentrations in GCF and PICF during healing after implant placement*.
| Fluid | Mediator | AMX grp day 0 | AMX grp day 6 | AMX grp day 13 | AMX grp day 20 | AZM grp day 0 | AZM grp day 6 | AZM grp day 13 | AZM grp day 20 |
|---|---|---|---|---|---|---|---|---|---|
| GCF | IL-6 | 98.2 ± 37.2 | 589 ± 115† | 264 ± 89.5 | 88.4 ± 21.5 | 26.7 ± 7.9 | 112 ± 69.4 | 142 ± 97.2 | 71.2 ± 31.3 |
| GCF | IL-8 | 1645 ± 378 | 1905 ± 342 | 1882 ± 458 | 3294 ± 736 | 1616 ± 317 | 2309 ± 340 | 2813 ± 391 | 2068 ± 475 |
| PICF | G-CSF | N/A | 92.0 ± 23.8 | 267 ± 121 | 348 ± 47.6 | N/A | 170 ± 53.9 | 212 ± 55.5 | 268 ± 60.1 |
| PICF | IL-8 | N/A | 6561 ± 1856 | 5263 ± 2457 | 12162 ± 5496‡ | N/A | 5509 ± 1527 | 2959 ± 1194 | 2104 ± 603‡ |
| PICF | MIP-1β | N/A | 542 ± 111 | 970 ± 324 | 1438 ± 443‡ | N/A | 437 ± 132 | 397 ± 88.9 | 334 ± 149‡ |
| PICF | IP-10 | N/A | 1312 ± 846 | 1362 ± 648 | 2187 ± 1326‡ | N/A | 263 ± 99.0 | 262 ± 83.1 | 221 ± 55.9‡ |
*
Concentration units: ng/ml
†
denotes a statistically significant difference from day 0 (P<0.05, repeated measures ANOVA; P<0.05, Holm-Sidak post-hoc test)
‡
denotes statistically significant differences between groups (P ≤ 0.05, Mann-Whitney rank sum test)