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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Lab Invest. 2015 Aug 17;95(11):1278–1290. doi: 10.1038/labinvest.2015.104

Figure 6.

Figure 6

Effect of pharmacologic EZH2 inhibition on viability in human RB cells and primary RPE. (A–C) Intracellular ATP, a direct measure of cell viability, was measured following co-culture of WERI-Rb1 (A) and Y79 (B) with the indicated concentrations of EZH2 inhibitors SAH-EZH2 (white bars) and GSK126 (black bars) for 48 h. (C) Culture of primary human fetal RPE with the indicated concentrations of SAH-EZH2 (white bars) and GSK126 (black bars) for 48 h. Human RB cells, but not primary RPE, were sensitive to high concentrations of EZH2 inhibitors. (* indicates significance at P < 0.05, compared to Con, control).