Table 7.
Summary data of children with and without apnea
| ITT | APP | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Any Apnea (0–12hrs) | No Apnea | Early Apnea (0–30 min) | Late Apnea (30 min – 12 hrs) | Late Apnea (30 min – 12 hrs, if discharged ≥12hrs post-op) | Any Apnea (0–12hrs) | No Apnea | Early Apnea (0–30 min) | Late Apnea (30 min – 12 hrs) | Late Apnea (30 min – 12 hrs, if discharged ≥12hrs post-op) | |
| N=25 | N=686 | N=15 | N=15 | N=14 | N=21 | N=621 | N=13 | N=13 | N=12 | |
| Regional Anaesthesia | 10 (40%) | 345 (50%) | 3 (20%) | 8 (53%) | 8 (57%) | 6 (29%) | 280 (55%) | 1 (8%) | 6 (46%) | 6 (50%) |
| Age (PMA) at surgery (weeks) | 41.2 (3.9) | 45.7 (4.5) | 41.5 (4.3) | 40.6 (3.2) | 40.3 (3.1) | 41.1 (4.1) | 45.7 (4.5) | 41.4 (4.5) | 40.6 (3.4) | 40.3 (3.3) |
| Weight at surgery (kg) | 3.3 (1.2) | 4.3 (1.1) | 3.6 (1.3) | 3.1 (0.9) | 3.0 (0.7) | 3.4 (1.2) | 4.3 (1.1) | 3.7 (1.3) | 3.2 (1.0) | 3.0 (0.8) |
| Haemoglobin level (g/100ml) | 9.8 (1.2) | 10.3 (2.0) | 10.1 (1.8) | 9.8 (2.0) | 9.7 (2.0) | 9.9 (1.8) | 10.3 (2.0) | 10.0 (1.8) | 10.0 (1.9) | 10.0 (2.0) |
| Gestational age at birth (weeks) | 30.8 (2.8) | 35.7 (3.9) | 31.4 (3.3) | 31.0 (2.6) | 30.6 (2.1) | 31.1(2.9) | 35.6 (3.9) | 31.7 (3.3) | 31.3 (2.8) | 30.8 (2.3) |
| Less than 37 weeks gestational age | 24 (96 %) | 365 (53%) | 14 (93%) | 14 (93%) | 14 (100%) | 20 (95%) | 335 (54%) | 12 (92%) | 12 (92%) | 12 (100%) |
| Blood glucose (mmol/l) | 6 (1.6) | 5.8 (1.9) | 6.0 (1.1) | 6.0 (1.8) | 6.1 (1.8) | 6.2 (1.6) | 5.8 (1.9) | 6.1 (1.1) | 6.2 (1.8) | 6.3 (1.8) |
| Apnea in previous 24 hours | 4 (16%) | 10 (1%) | 1 (7%) | 4 (27%) | 4 (29%) | 4 (19%) | 10 (2%) | 1 (8%) | 4 (31%) | 4 (33%) |
| Ever treated with a methyl xanthine | 14 (56%) | 98 (14%) | 7 (47%) | 10 (67%) | 10 (71%) | 12 (57%) | 91 (15%) | 6 (46%) | 9 (69%) | 9 (75%) |
| Ever ventilated with a tracheal tube pre-operatively | 8 (32%) | 83 (12%) | 3 (20%) | 6 (40%) | 6 (43%) | 6 (29%) | 76 (12%) | 3 (23%) | 4 (31%) | 4 (33%) |
| Ever needed oxygen therapy (apart from at birth) | 18 (72%) | 156 (23%) | 9 (60%) | 13 (87%) | 13 (93%) | 15 (71%) | 141 (23%) | 8 (62%) | 11 (85%) | 11 (92%) |
| Smoker in the household | 6 (24%) | 212 (31%) | 4 (27%) | 4 (27%) | 3 (21%) | 6 (29%) | 191 (31%) | 4 (31%) | 4 (31%) | 3 (25%) |
| Any opioids given prior to apnea* | 1 (4 %) | 14 (2%) | 0 (0.0) | 1 (7%) | 1 (5%) | 12 (2%) | 0 (0.0) | 1 (8%) | ||
| Minimum intra-operative temperature | 36.0 (0.8) | 36.0 (0.8) | 36.0 (0.6) | 36.0 (1.0) | 36.0 (1.0) | 36.0 (0.8) | 36.1 (0.8) | 36.0 (0.6) | 36.1 (0.9) | 36.2 (1.0) |
| Surgery duration (mins) | 30 (22 to 39) | 28 (20 to 39) | 29 (24 to 39) | 26 (20 to 41) | 28 (20 to 41) | 29 (22 to 32) | 27 (20 to 38) | 28 (24 to 32) | 26 (20 to 31) | 28 (20 to 36) |
APP = As Per Protocol; ITT = Intention to Treat; Mins = Minutes; PMA = Postmenstrual Age;
Data as frequency and percentage of non-missing data or mean and standard deviation.
*
Note that the data are incomplete with respect to opioid administration after 1 hour so only early apnea data are shown.