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. Author manuscript; available in PMC: 2016 Dec 1.

Published in final edited form as: Aliment Pharmacol Ther. 2015 Oct 1;42(0):1303–1314. doi: 10.1111/apt.13413

Olmesartan Acid alone can increase IL-15 and disrupt ZO-1. Caco-2 cells were cultured for 5–7 days, treated with 30 micromolar olmesartan acid, 30 micromolar DMSO, and/or 30 micromolar diacetyl (medoxomil) for four hours and then stained for IL-15 (red) (A–C) or ZO-1 (green) (D–F). Panels A and D are DMSO (diluent for olmesartan acid) alone. Panels B and E are olmesartan acid and panel C is olmesartan medoxomil. Panel F is diacetyl alone. Panel G is a graph displaying the immunofluorescence of ZO-1 staining of Caco2 cells treated with the different reagents, where each dot represents a different well of Caco-2 cells treated with the listed reagent.

Olmesartan Acid alone can increase IL-15 and disrupt ZO-1. Caco-2 cells were cultured for 5–7 days, treated with 30 micromolar olmesartan acid, 30 micromolar DMSO, and/or 30 micromolar diacetyl (medoxomil) for four hours and then stained for IL-15 (red) (A–C) or ZO-1 (green) (D–F). Panels A and D are DMSO (diluent for olmesartan acid) alone. Panels B and E are olmesartan acid and panel C is olmesartan medoxomil. Panel F is diacetyl alone. Panel G is a graph displaying the immunofluorescence of ZO-1 staining of Caco2 cells treated with the different reagents, where each dot represents a different well of Caco-2 cells treated with the listed reagent.