Table 1. Clinical data and outcomes of the two groups.
AED group (n = 44) | No AED group (n = 40) | p value | |
---|---|---|---|
Age (mean ± SD) | 52.8 ± 12.7 | 52.4 ± 13.9 | 0.906 |
Gender | 0.835 | ||
Male | 21 (47.7%) | 20 (50.0%) | |
Female | 23 (52.3%) | 20 (50.0%) | |
AED | NA | ||
Levetiracetam | Valproic acid | NA | |
Valproic acid | 9 (20.5%) | NA | |
Underlying disease | 0.673 | ||
HTN | 9 (20.5%) | 8 (20.0%) | |
DM | 3 (6.8%) | 3 (7.5%) | |
Dyslipidemia | 6 (13.6%) | 4 (10.0%) | |
Smoking | 8 (18.2%) | 6 (15.0%) | |
Aneurysm location | 0.104 | ||
ICA | 10 (22.7%) | 11 (27.5%) | |
ACA | 15 (34.1%) | 10 (25.0%) | |
MCA | 17 (38.6%) | 9 (22.5%) | |
Posterior circulation | 2 (4.5%) | 10 (25.0%) | |
Aneurysm shape | 0.032 | ||
Saccular | 44 (100%) | 36 (90.0%) | |
Dissecting | 0 (0%) | 4 (10.0%) | |
Aneurysm size (mm, mean ± SD) | 6.32 ± 2.94 | 7.65 ± 5.59 | 0.177 |
Initial HHG | 0.990 | ||
1 | 1 (2.3%) | 0 (0.0%) | |
2 | 29 (65.9%) | 22 (55.0%) | |
3 | 18 (40.9%) | 14 (35.0%) | |
Fisher grade | 0.980 | ||
1 | 0 (0.0%) | 0 (0.0%) | |
2 | 7 (15.9%) | 7 (17.5%) | |
3 | 29 (65.9%) | 26 (65.0%) | |
4 | 8 (18.2%) | 7 (17.5%) | |
EVD or Shunt | 9 (20.5%) | 5 (12.5%) | 0.298 |
Hydrocephalus | 10 (22.7%) | 4 (10%) | 0.254 |
Symptomatic vasospasm | 7 (15.9%) | 5 (12.5%) | 0.772 |
Procedure related complication | 3 (6.8%) | 1 (2.5%) | 0.621 |
Systemic complication | 9 (20.5%) | 2 (5.0%) | 0.106 |
Treatment modality | < 0.001 | ||
Microsurgery | 37 (84.1%) | 7 (17.5%) | |
Endovascular surgery | 7 (15.9%) | 33 (82.5%) | |
Clinical outcome at discharge | 0.607 | ||
Favorable (mRS 0~2) | 38 (86.4%) | 36 (90.0%) | |
Poor (mRS 3~6) | 6 (13.6%) | 4 (10.0%) | |
Clinical outcome on 6-month | 0.178 | ||
Favorable (mRS 0~2) | 38 (86.4%) | 38 (95.0%) | |
Poor (mRS 3~6) | 6 (13.6%) | 2 (5.0%) |
ACA = anterior cerebral artery; AED = antiepileptic drug; DM = diabetes mellitus; EVD = external ventricular drainage; HTN = hypertension; ICA = internal carotid artery; MCA = middle cerebral artery; NA = not applicable; mRS = modified Rankin Scale; SD = standard deviation