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Mutations in SH2B3 decrease expression of LNK. (a) Compound mutations in the Plekstrin and Src Homology 2 domains are presented for each patient found to harbor SH2B3 lesions on whole exome sequencing. (b) Western blot analysis from whole cell lysates using anti-LNK and anti-B-actin antibodies. Commensurate with the allelic fraction of each mutation (UPN1420-Relapse, 31%, UPN2531-Diagnosis, 37%), the expression of LNK is decreased.
